tailieunhanh - Báo cáo khoa học: "A study on the immunocytochemical localization of neurofascin in rat sciatic nerve"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: A study on the immunocytochemical localization of neurofascin in rat sciatic nerve | J. Vet. Sci. 2000 1 2 67-71 OURNAL OF Veterinary Science A study on the immunocytochemical localization of neurofascin in rat sciatic nerve Byung-joon Chang Ik-hyun Cho and Peter J. Brophy1 Department of Anatomy and Histology College of Veterinary Medicine Konkuk University Seoul 143-701 Korea Department of Preclinical Veterinary Sciences University of Edinburgh Edinburgh EH9 1QH UK We examined the localization of neurofascin NF in the sciatic nerve of rat. In the myelinated fibers neurofascin localizes strongly in the nodal axolemma except the small central cleft and also expresses in the paranodes and weakly in the Schmidt-Lanterman incisures. In the paranodes NF localizes around the axolemma and it expresses in the apposing membrane of paranodal loops. Axoplasm compact myelin and cytoplasm of Schwann cell do not express NF at all. In the Schmidt-Lanterman incisures NF is expressed weakly along the Schwann cell membrane. We propose that neurofascin may be a plasmalemmal integral protein of Schwann cell in the paranode and plays some important roles for the maintenance of axo-glial junctions at the paranode. It may also have some roles for maintaining the structure of Schmidt-Lanterman incisure and have some relations with proteins localizing in the node. Key words neurofascin axo-glial junction Schmidt-Lanterman incisure immunocytochemistry Introduction Neurofascin is an axon-associated member of the L1 subgroup of the immunoglobulin superfamily that is implicated in the processes during the development of the nervous system such as cell adhesion cell migration neurite outgrowth and fasciculation 3 10 11 14 20 . Neurofascin is concentrated in developing fiber tracts at early stages of development 15 17 . At later stages of development neurofascin is more widely expressed in the nervous system 13 . Neurofascin is characterized by extracellular domains comprised of 6 immunoglobulin domains and 4 fibronectin type III domains and cytoplasmic domains containing an .

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