tailieunhanh - Báo cáo hóa học: " The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2 | Nanoscale Res Lett 2009 4 1275-1285 DOI S11671-009-9393-8 NANO EXPRESS The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2 Linglan Ma Jinfang Zhao Jue Wang Jie Liu Yanmei Duan Huiting Liu Na Li Jingying Yan Jie Ruan Han Wang Fashui Hong Received 11 June 2009 Accepted 3 July 2009 Published online 1 August 2009 to the authors 2009 Abstract Although it is known that nano-TiO2 or other nanoparticles can induce liver toxicities the mechanisms and the molecular pathogenesis are still unclear. In this study nano-anatase TiO2 5 nm was injected into the abdominal cavity of ICR mice for consecutive 14 days and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA histopathological changes and hepatocytes apoptosis of mice liver and the liver function damaged by higher doses nano-anatase TiO2. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO2 can significantly alter the mRNA and protein expressions of several inflammatory cytokines including nucleic factor-jB macrophage migration inhibitory factor tumor necrosis factor-a interleukin-6 inter-leukin-1b cross-reaction protein interleukin-4 and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nanoanatase TiO2-induced liver toxicity. Keywords Mice Nano-anatase TiO2 Liver Inflammatory cytokines Histopathological changes Linglan Ma Jinfang Zhao and Jue Wang contributed equally to this work. L. Ma J. Zhao J. Wang J. Liu Y. Duan H. Liu N. Li J. Yan J. Ruan H. Wang F. Hong El Medical College of Soochow University 215123 Suzhou People s Republic of China e-mail Hongfsh_cn@ Introduction Titanium dioxide nanoparticles nano-TiO2 100 nm are widely used in the cosmetics pharmaceutical and paint industries as a coloring material because of its high stability anticorrosion and photocatalysis. More and more nanoparticles are brought into the environment with