tailieunhanh - Báo cáo hóa học: " A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host–Guest Effect"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host–Guest Effect | Nanoscale Res Lett 2009 4 738-747 DOI S11671-009-9314-X NANO EXPRESS A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host-Guest Effect Yuanpeng Wu Fang Zuo Zhaohui Zheng Xiaobin Ding Yuxing Peng Received 16 February 2009 Accepted 2 April 2009 Published online 23 April 2009 to the authors 2009 Abstract A novel route has been developed to prepared b-cyclodextrin b-CD functionalized magnetic nanoparticles MNPs . The MNPs were first modified with monot-osyl-poly ethylene glycol PEG silane and then tosyl units were displaced by amino-b-CD through the nucleophilic substitution reaction. The monotosyl-PEG silane was synthesized by modifying a PEG diol to form the corresponding monotosyl-PEG followed by a reaction with 3-isocyanatopropyltriethoxysilane IPTS . The success of the synthesis of the monotosyl-PEG silane was confirmed with 1H NMR and Fourier transform infrared FTIR spectroscopy. The analysis of FTIR spectroscopy and X-ray photoelectron spectroscopy XPS confirmed the immobilization of b-CD onto MNPs. Transmission electron microscopy TEM indicated that the b-CD functionalized MNPs were mostly present as individual nonclustered units in water. The number of b-CD molecules immobilized on each MNP was about 240 according to the thermogravimetric analysis TGA results. The Y. Wu Z. Zheng X. Ding Y. Peng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 People s Republic of China e-mail xbding@ Y. Peng e-mail yxpeng@ F. Zuo Research Branch of Functional Materials State Key Laboratory of Electronic Films Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 People s Republic of China Y. Wu Graduate School of the Chinese Academy of Sciences Beijing 100049 People s Republic of China as-prepared b-CD functionalized MNPs were used to detect dopamine with the assistance of a magnet. Keywords b-Cyclodextrin Magnetic nanoparticles Molecular .