tailieunhanh - MELANOMA CRITICAL DEBATES - PART 3

Vitamin D tổng hợp theo thay đổi quang phổ tia cực tím. In: Young AR, Björn LO, Moan J, Nultsch W, eds. Photobiology UV môi trường. New York: Hội nghị Báo chí, 1993: 185-202. 70 nhãn hiệu R, Foley PA, Jolley D, Knight KR, Harrison J, Thompson SC. Hiệu quả của việc sử dụng kem chống nắng thường xuyên nồng độ vitamin D | 48 CHAPTER 3 69 Webb AR. Vitamin D synthesis under changing UV spectra. In Young AR Bjorn LO Moan J Nultsch W eds. Environmental UVPhotobiology. New York Plenum Press 1993 185-202. 70 Marks R Foley PA Jolley D Knight KR Harrison J Thompson SC. The effect of regular sunscreen use on vitamin D levels in an Australian population results of a randomised controlled trial. Arch Dermatol 1995 131 415-21. 71 Sollitto RB Kraemer KH DiGiovanna JJ. Normal vitamin D levels can be maintained despite rigorous photoprotection six years experience with xeroderma pigmentosum. J Am Acad Dermatol 1997 37 942-7. 72 Knowland J McKenzie EA McHugh PJ Cridland NA. Sunlight-induced mutagenicity of a common sunscreen ingredient. FEBS Lett 1993 324 309-13. 73 Dunford R Salinaro A Cai L et al. Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients. FEBS Lett 1997 418 87-90. 74 Stevenson C Davies RJH. Photosensitisation of guanine-specific DNA damage by 2-phenylbenzimidazole and the sunscreen agent 2-phenyl-benzimidazole-5-sulfonic acid. Chem Res Toxicol 1999 12 38M5. Melanoma Critical Debates Edited by Julia A. Newton Bishop Martin Gore Copyright 2002 Blackwell Science Ltd 4 Why are redheads so susceptible to melanoma Jonathan Rees Introduction The major covariants of most forms of skin cancer including melanoma are pigmentary phenotype and ambient ultraviolet radiation UVR 1-6 . In general and ignoring recent human migrations areas with ambient UVR load are inhabited by people with darker skin 7 . The major genetic risk factor for melanoma is therefore skin colour and by association hair colour the major environmental risk factor is UVR. Differences in the degree and type of pigmentation account not just for differences in melanoma rates between broad groupings such as white or black people but also exist within these groups. For example and relevant to the present chapter it has been known for a long time that those with Celtic ancestry are more susceptible to .

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