tailieunhanh - Báo cáo hóa học: " Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent | Nanoscale Res Lett 2009 4 618-626 DOI s11671-009-9286-x NANO EXPRESS Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent Zhijin Chen Dexin Yu Shaojie Wang Na Zhang Chunhong Ma Zaijun Lu Received 16 December 2008 Accepted 5 March 2009 Published online 18 March 2009 to the authors 2009 Abstract Accurate diagnosis in early stage is vital for the treatment of Hepatocellular carcinoma. The aim of this study was to investigate the potential of poly lactic acid-polyethylene glycol gadolinium-diethylenetriamine-pentaacetic acid PLA-PEG Gd-DTPA nanocomplexes using as biocompatible molecular magnetic resonance imaging MRI contrast agent. The PLA-PEG Gd-DTPA nanocomplexes were obtained using self-assembly nanotechnology by incubation of PLA-PEG nanoparticles and the commercial contrast agent Gd-DTPA. The physicochemical properties of nanocomplexes were measured by atomic force microscopy and photon correlation spectroscopy. The T1-weighted MR images of the nanocomplexes were obtained in a T clinical MR imager. The stability study was carried out in human plasma and the distribution in vivo was investigated in rats. The mean size of the PLA-PEG Gd-DTPA nanocomplexes was nm and the polydispersity index was and the zeta potential was mV. The results of MRI test confirmed that the PLA-PEG Gd-DTPA nanocomplexes possessed the ability of MRI and the direct correlation between the MRI Z. Chen N. Zhang School of Pharmaceutical Science Shandong University 44 Wenhua Xi Road 250012 Ji nan People s Republic of China e-mail zhangnancy9@ D. Yu C. Ma Department of Radiology Medicine Affiliated Qilu Hospital Shandong University 44 Wenhua Xi Road 250012 Ji nan People s Republic of China S. Wang Z. Lu School of Chemistry and Chemical Engineering Shandong University 27 Shanda Road 250012 Ji nan People s Republic of China e-mail imaging intensities and the nano-complex concentrations was observed r . The .