tailieunhanh - Báo cáo hóa học: " Synthesis and Cytotoxicity of Y2O3 Nanoparticles of Various Morphologies"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Synthesis and Cytotoxicity of Y2O3 Nanoparticles of Various Morphologies | Nanoscale Res Lett 2010 5 263-273 DOI S11671-009-9445-0 NANO EXPRESS Synthesis and Cytotoxicity of Y2O3 Nanoparticles of Various Morphologies Tamar Andelman Simon Gordonov Gabrielle Busto Prabhas V. Moghe Richard E. Riman Received 8 June 2009 Accepted 24 September 2009 Published online 24 November 2009 to the authors 2009 Abstract As the field of nanotechnology continues to grow evaluating the cytotoxicity of nanoparticles is important in furthering their application within biomedicine. Here we report the synthesis characterization and cytotoxicity of nanoparticles of different morphologies of yttrium oxide a promising material for biological imaging applications. Nanoparticles of spherical rod-like and platelet morphologies were synthesized via solvothermal and hydrothermal methods and characterized by transmission electron microscopy TEM X-ray diffraction XRD light scattering surface area analysis thermogravimetric analysis TGA and zeta potential measurements. Nanoparticles were then tested for cytotoxicity with human foreskin fibroblast HFF cells with the goal of elucidating nanoparticle characteristics that influence cytotoxicity. Cellular response was different for the different morphologies with spherical particles exhibiting no cytotoxicity to HFF cells rod-like particles increasing cell proliferation and platelet particles markedly cytotoxic. However due to differences in the nanoparticle chemistry as determined T. Andelman R. E. Riman El Department of Materials Science Engineering Rutgers The State University of New Jersey 607 Taylor Road Piscataway NJ 08854 USA e-mail riman@ T. Andelman S. Gordonov G. Busto P. V. Moghe R. E. Riman Department of Biomedical Engineering Rutgers The State University of New Jersey 599 Taylor Road Piscataway NJ 08854 USA P. V. Moghe Department of Chemical and Biochemical Engineering Rutgers The State University of New Jersey 98 Brett Road Piscataway NJ 08854 USA through the characterization techniques it