tailieunhanh - Báo cáo khoa học: The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species – oxygen-binding equilibria, kinetics and molecular dynamics

The dominant perciform suborder Notothenioidei is an excellent study group for assessing the evolution and functional importance of biochemical adaptations to temperature. The availability of notothenioid taxa in a wide range of latitudes (Antarctic and non-Antarctic) provides a tool to enable identification of physiological and biochemical characteristics gained and lost during evolutionary history. | The hemoglobins of the sub-Antarctic fish Cottoperca gobio a phyletically basal species - oxygen-binding equilibria kinetics and molecular dynamics Daniela Giordano1 Leonardo Boechi2 Alessandro Vergara3 Marcelo A. Marti2 Uri Samuni4 David Dantsker5 Luigi Grassi1 Dario A. Estrin2 Joel M. Friedman5 Lelio Mazzarella3 Guido di Prisco1 and Cinzia Verde1 1 Institute of Protein Biochemistry NationalResearch Council CNR Naples Italy 2 Departamento de Quimica Inorganica Analitica y Quimica Fisica INQUIMAE-CONICET Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Argentina 3 Department of Chemistry University of Naples Federico II Naples Italy 4 Department of Chemistry and Biochemistry Queens College City University New York Flushing NY USA 5 Department of Physiology and Biophysics Albert Einstein College of Medicine Bronx NY USA Keywords Antarctica computer simulation hemoglobin ligand-binding properties oxygen affinity Correspondence C. Verde Institute of Protein Biochemistry CNR Via Pietro Castellino 111 I-80131 Naples Italy Fax 39 81 6132710 Tel 39 81 6132710 E-mail Present address University di Torino Dipartimento di Fisica Teorica via P. Giuria 1 - 10125 Torino Database The protein sequence reported in this paper has been submitted to the UniProt Knowledgebase under the accession numbers P84652 b chain P84653 a1 chain and P85083 a2 chain . The coordinates of the protein modelare available at http PMDB under ID PM0075620. Received 12 December 2008 revised 17 January 2009 accepted 9 February 2009 doi The dominant perciform suborder Notothenioidei is an excellent study group for assessing the evolution and functional importance of biochemical adaptations to temperature. The availability of notothenioid taxa in a wide range of latitudes Antarctic and non-Antarctic provides a tool to enable identification of physiological and biochemical characteristics gained and lost during evolutionary .