tailieunhanh - báo cáo hóa học: " Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study | Health and Quality of Life Outcomes BioMed Central Open Access Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia a prospective observational study Machteld AG de Vries 1 Raphaele RLvan Litsenburg 1 Jaap Huisman2 Martha A Grootenhuis3 A Birgitta Versluys4 Gert Jan L Kaspers1 and Reinoud JBJ Gemke1 Address Department of paediatrics and division of oncology-haematology VU University Medical Centre Amsterdam The Netherlands 2Department of medical psychology VU University Medical Centre Amsterdam The Netherlands 3Paediatric Psychosocial Department Emma Children s Hospital Amsterdam The Netherlands and 4Department of paediatrics division of oncology-haematology Wilhelmina Children s Hospital University Medical Centre Utrecht The Netherlands Email Machteld AG de Vries - machteld_99@ Raphaele RL van Litsenburg - litsenburg@ Jaap Huisman - Martha A Grootenhuis - A Birgitta Versluys - Gert Jan L Kaspers - Reinoud JBJ Gemke - Corresponding author fEqual contributors Published 26 November 2008 Received 22 April 2008 J Accepted 26 November 2008 Health and Quality of Life Outcomes 2008 6 103 doi 1477-7525-6-103 This article is available from http content 6 1 103 2008 de Vries et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Glucocorticoids are important in the treatment of childhood acute lymphoblastic leukaemia ALL . However cyclic administration of high dose glucocorticoids may cause rapid and substantial changes in quality of life QoL . The maintenance phase of the Dutch ALL-9 protocol consisted of alternating two weeks .