tailieunhanh - Báo cáo sinh học: "Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | Brenu et al. Journal of Translational Medicine 2011 9 81 http content 9 1 81 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome Myalgic Encephalomyelitis 2 2 2 Ekua W Brenu 1 Mieke L van Driel 1 Don R Staines 1 Kevin J Ashton Sandra B Ramos James Keane Nancy G Klimas4 and Sonya M Marshall-Gradisnik1 2 Abstract Background Chronic Fatigue Syndrome Myalgic Encephalomyelitis CFS ME is characterised by severe prolonged fatigue and decreases in cognition and other physiological functions resulting in severe loss of quality of life difficult clinical management and high costs to the health care system. To date there is no proven pathomechanism to satisfactorily explain this disorder. Studies have identified abnormalities in immune function but these data are inconsistent. We investigated the profile of markers of immune function including novel markers in CFS ME patients. Methods We included 95 CFS ME patients and 50 healthy controls. All participants were assessed on natural killer NK and CD8 T cell cytotoxic activities Th1 and Th2 cytokine profile of CD4 T cells expression of vasoactive intestinal peptide receptor 2 VPACR2 levels of NK phenotypes CD56bright and CD56dim and regulatory T cells expressing FoxP3 transcription factor. Results Compared to healthy individuals CFS ME patients displayed significant increases in IL-10 IFN-g TNF-a CD4 CD25 T cells FoxP3 and VPACR2 expression. Cytotoxic activity of NK and CD8 T cells and NK phenotypes in particular the CD56bright NK cells were significantly decreased in CFS ME patients. Additionally granzyme A and granzyme K expression were reduced while expression levels of perforin were significantly increased in the CFS ME population relative to the control population. These data suggest significant dysregulation of the immune system in CFS ME patients. Conclusions Our study found immunological .