tailieunhanh - Báo cáo sinh học: "SULFs in human neoplasia: implication as progression and prognosis factors"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: SULFs in human neoplasia: implication as progression and prognosis factors | Bret et al. Journal of Translational Medicine 2011 9 72 http content 9 1 72 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access SULFs in human neoplasia implication as progression and prognosis factors Caroline Bret1 2 3 Jerome Moreaux1 Jean-Frangois Schved2 3 Dirk Hose4 5 and Bernard Klein1 3 Abstract Background The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O sulfate groups within the heparan chains. Their action can modulate signaling processes many of which with key relevance for cancer development and expansion. SULF1 has been associated with tumor suppressor effects in various models of cancer whereas SULF2 dysregulation was in relation with protumorigenic actions. However other observations argue for contradictory effects of these sulfatases in cancer suggesting the complexity of their action in the tumor microenvironment. Methods We compared the expression of the genes encoding SULF1 SULF2 and heparan sulfate proteoglycans in a large panel of cancer samples to their normal tissue counterparts using publicly available gene expression data including the data obtained from two cohorts of newly-diagnosed multiple myeloma patients the Oncomine Cancer Microarray database the Amazonia data base and the ITTACA database. We also analysed prognosis data in relation with these databases. Results We demonstrated that SULF2 expression in primary multiple myeloma cells was associated with a poor prognosis in two independent large cohorts of patients. It remained an independent predictor when considered together with conventional multiple myeloma prognosis factors. Besides we observed an over-representation of SULF2 gene expression in skin cancer colorectal carcinoma testicular teratoma and liver cancer compared to their normal tissue counterpart. We found that SULF2 was .