tailieunhanh - Báo cáo sinh học: " Ozone acting on human blood yields a hormetic dose-response relationship"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Ozone acting on human blood yields a hormetic dose-response relationship | Bocci et al. Journal of Translational Medicine 2011 9 66 http content 9 1 66 JOURNAL OF TRANSLATIONAL MEDICINE REVIEW Open Access Ozone acting on human blood yields a hormetic dose-response relationship Velio A Bocci1 lacopo Zanardi2 and Valter Travagli2 Abstract The aim of this paper is to analyze why ozone can be medically useful when it dissolves in blood or in other biological fluids. In reviewing a number of clinical studies performed in Peripheral Arterial Diseases PAD during the last decades it has been possible to confirm the long-held view that the inverted U-shaped curve typical of the hormesis concept is suitable to represent the therapeutic activity exerted by the so-called ozonated autohemotherapy. The quantitative and qualitative aspects of human blood ozonation have been also critically reviewed in regard to the biological therapeutic and safety of ozone. It is hoped that this gas although toxic for the pulmonary system during prolonged inhalation will be soon recognized as a useful agent in oxidative-stress related diseases joining other medical gases recently thought to be of therapeutic importance. Finally the elucidation of the mechanisms of action of ozone as well as the obtained results in PAD may encourage clinical scientists to evaluate ozone therapy in vascular diseases in comparison to the current therapies. Introduction Ozone is a double-faceted gas. It has a crucial protective relevance in partially blocking mutagenic and carcinogenic UV radiations emitted by the sun wavelengths of 100-280 nm in the stratosphere 1 while its increasing concentration in the troposphere causes severe pulmonary damage and increased mortality 2 3 . In spite of this drawback there are growing experimental and clinical evidences about the medical use of ozone 4-11 . Since XVI Century Paracelsus had ingeniously guessed that all things are poison and nothing is without poison and only the right dose differentiates a poison from a .