tailieunhanh - Báo cáo sinh học: " Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection | Virology Journal BioMed Central Research Role of CDI5I A tetraspanin in porcine reproductive and respiratory syndrome virus infection Kumar Shanmukhappa1 Jeong-Ki Kim2 and Sanjay Kapil 3 Open Access Address Division of Pediatric Gastroenterology Hepatology and Nutrition Cincinnati Children s Hospital Medical Center University of Cincinnati. Cincinnati OH 42229 USA 2Division of Virology Department of Infectious Diseases St. Jude Children s Research Hospital Memphis TN 38105 USA and 3Oklahoma Animal Disease Diagnostic Laboratory Center for Veterinary Health Sciences Oklahoma State University Stillwater OK 74078 USA Email Kumar Shanmukhappa - shatm2@ Jeong-Ki Kim - Sanjay Kapil - Corresponding author Published 16 June 2007 Received 4 April 2007 Accepted 16 June 2007 Virology Journal 2007 4 62 doi l 743-422X-4-62 This article is available from http content 4 1 62 2007 Shanmukhappa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Porcine reproductive and respiratory syndrome virus PRRSV is a RNA virus causing respiratory and reproductive diseases in swine. The susceptibility for PRRSV varies between the different breeds of swine. In cell culture PRRSV virus can be propagated in primary porcine alveolar macrophages and some African green monkey kidney cell lines such as MARC-145 cells. Previous studies have shown that 3 untranslated region UTR RNAs of the arteriviruses play an important role in the replication of the virus through interactions with cellular proteins. To better understand the differences in the replication capability of PRRSV in different cell lines we sought to identify the host cellular proteins .