tailieunhanh - Báo cáo sinh học: "Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study | Alves et al. Journal of Translational Medicine 2011 9 23 http content 9 1 23 TRANSLATIONAL MEDICINE RESEARCH Open Access Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock a prospective study Brunna E Alves 1 Silmara AL Montalvao1 Francisco JP Aranha1 Irene Lorand-Metze2 Carmino A De Souza2 Joyce M Annichino-Bizzacchi2 Erich V De Paula1 Abstract Background Septic shock is the most feared complication of chemotherapy-induced febrile neutropenia. So far there are no robust biomarkers that can stratify patients to the risk of sepsis complications. The VEGF-A axis is involved in the control of microvascular permeability and has been involved in the pathogenesis of conditions associated with endothelial barrier disruption such as sepsis. sFlt-1 is a soluble variant of the VEGF-A receptor VEGFR-1 that acts as a decoy receptor down-regulating the effects of VEGF-A. In animal models of sepsis sFlt-1 was capable to block the barrier-breaking negative effects of VEGF-A and to significantly decrease mortality. In non-neutropenic patients sFlt-1 has been shown to be a promising biomarker for sepsis severity. Methods We prospectively evaluated concentrations of sFlt-1 and VEGF-A at different time-points during febrile neutropenia and evaluated the association of these levels with sepsis severity and septic shock development. Results Neutropenic patients that evolved with septic shock n 10 presented higher levels of sFlt-1 and VEGF-A measured 48 hours after fever onset than patients with non-complicated sepsis n 31 and levels of these biomarkers correlated with sepsis severity scores. Estimation of the diagnostic accuracy of sFlt-1 levels for the discrimination of patients that evolved to septic shock yielded promising results in our study population. Discussion Our data suggest that sFlt-1 and VEGF-A could be useful biomarkers for sepsis severity in patients with febrile neutropenia. In addition the .