tailieunhanh - Báo cáo sinh học: " Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection | Virology Journal BioMed Central Short report Open Access Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection Matthijs Raaben1 Alexandra WC Einerhand2 Lucas JATaminiau2 Michel van Houdt2 Janneke Bouma2 Rolien H Raatgeep2 Hans A Buller2 Cornelis AM de Haan1 and John WA Rossen 2 3 4 Address 1Virology Division Department of Infectious Diseases Immunology Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands 2Laboratory of Pediatrics Erasmus MC- Sophia Children s Hospital Rotterdam The Netherlands 3Department of Virology Eijkman-Winkler Institute University Medical Centre Utrecht Utrecht The Netherlands and 4Laboratory of Medical Microbiology and Immunology St. Elisabeth Hospital Tilburg The Netherlands Email Matthijs Raaben - Alexandra WC Einerhand - Lucas JATaminiau - taminiau42@ Michel van Houdt - Janneke Bouma - Rolien H Raatgeep - Hans A Buller - Cornelis AM de Haan - John WA Rossen - Corresponding author Published 7 June 2007 Received 28 April 2007 Accepted 7 June 2007 Virology Journal 2007 4 55 doi l 743-422X-4-55 This article is available from http content 4 1 55 2007 Raaben et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Cyclooxygenases COXs play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus MHV infection cycle. Blocking COX activity by different inhibitors or by RNA interference .