tailieunhanh - báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight) | Brod et al. Health and Quality of Life Outcomes 2010 8 19 http content 8 1 19 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Development and validation of the Treatment Related Impact Measure of Weight TRIM-Weight Meryl Brod1 Mette Hammer2 Nana Kragh2 Suzanne Lessard1 Donald M Bushnell3 Abstract Background The use of prescription anti-obesity medication AOM is becoming increasingly common as treatment options grow and become more accessible. However AOM may not be without a wide range of potentially negative impacts on patient functioning and well being. The Treatment Related Impact Measure TRIMWeight is an obesity treatment-specific patient reported outcomes PRO measure designed to assess the key impacts of prescription anti-obesity medication. This paper will present the validation findings for the TRIM-Weight. Methods The online validation battery survey was administered in four countries the . . Australia and Canada . Eligible subjects were over age eighteen currently taking a prescription AOM and were currently or had been obese during their life. Validation analyses were conducted according to an a priori statistical analysis plan. Item level psychometric and conceptual criteria were used to refine and reduce the preliminary item pool and factor analysis to identify structural domains was performed. Reliability and validity testing was then performed and the minimally importance difference MID explored. Results Two hundred and eight subjects completed the survey. Twenty-one of the 43 items were dropped and a five-factor structure was achieved Daily Life Weight Management Treatment Burden Experience of Side Effects and Psychological Health. A-priori criteria for internal consistency and test-retest coefficients for the total score and all five subscales were met. All pre-specified hypotheses for convergent and known group validity were also met with the exception of the domain of Daily Life proven in an ad hoc analysis as well as .