tailieunhanh - Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain | EJNMMI Research SpringerOpen0 This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text HTML versions will be made available soon. PET kinetics of radiolabeled antidepressant N-methyl-11C mirtazapine in the human brain EJNMMI Research 2011 1 36 doi 2191-219X-1-36 Ole L Munk olmunk@ Donald F Smith dfsmithdfsmith@ ISSN 2191-219X Article type Original research Submission date 9 September 2011 Acceptance date 15 December 2011 Publication date 15 December 2011 Article URL http content 1 1 36 This peer-reviewed article was published immediately upon acceptance. It can be downloaded printed and distributed freely for any purposes see copyright notice below . For information about publishing your research in EJNMMI Research go to http authors instructions For information about other SpringerOpen publications go to http 2011 Munk and Smith licensee Springer. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. PET kinetics of radiolabeled antidepressant -methyl-11C mirtazapine in the human brain Ole L Munk 1 and Donald F Smith2 department of Nuclear Medicine PET Centre Aarhus University Hospital N0rrebrogade 44 Aarhus C 8000 Denmark 2Center for Psychiatric Research Aarhus University Hospital Risskov 8240 Denmark Corresponding author olmunk@ Email addresses OLM olmunk@ DFS dfsmithdfsmith@ Abstract Background We compared six kinetic models with and without the requirement of arterial cannulation for estimating the binding potential of A-methyl-11C mirtazapine in the living human brain. Methods Distribution volumes of A-methyl-11C mirtazapine in brain regions were estimated using single- and .