tailieunhanh - Báo cáo y học: "Malaria genomics meets drug-resistance phenotyping in the field"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Malaria genomics meets drug-resistance phenotyping in the field. | X Genome Biology Meeting report Malaria genomics meets drug-resistance phenotyping in the field Paul Hunt Bronwyn MacInnis and Cally Roper Addresses Institute for Immunology and Infection Research University of Edinburgh Ashworth Laboratory Kings Buildings Edinburgh EH9 3JT UK. Wellcome Trust Sanger Institute Hinxton CB10 ISA UK. tLondon School of Hygiene and Tropical Medicine University of London Keppel Street London WC1E 7HT uK. Correspondence Paul Hunt. Email Abstract A report of the 2nd Wellcome Trust Conference on Genomic Epidemiology of Malaria Hinxton UK 14-17 June 2009. New genomic technologies and analyses present opportunities for understanding the evolution of drug resistance in malaria parasites and for identifying associated genetic markers. In addition such techniques may be of use in tracking and containing the evolution of resistance. Given the appearance of field reports of reduced sensitivity to new artemisinin-based drugs the second of the Wellcome Trust conferences on the application of genomics to malaria epidemiology provided a timely opportunity to review scientific and public-health developments and to discuss future research surveillance and intervention priorities. At this meeting the focus was on genomics and drug resistance. Here we report a few highlights. Is artemisinin resistance already a reality The control of malarial disease by drug treatment is at a critical stage. The old therapies such as chloroquine and antifolates have largely failed and we are increasingly dependent upon artemisinin combination therapies ACTs . Some scientists have questioned whether resistance to artemisinin would ever arise. Recently however reports of reduced susceptibility to artemisinin derivatives such as artesunate artemether and dihydroartemisin are accumulating from Thailand and Cambodia. The continued emergence of artemisinin resistance would represent a grave risk to public health. Arjen Dondorp Mahidol University Bangkok .