tailieunhanh - Báo cáo y học: "otifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons. | Open Access Researc h Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons Rui Liu Sridhar Hannenhalli and Maja Bucan Address Department of Genetics and Penn Center for Bioinformatics University of Pennsylvania Philadelphia PA 19104 USA. Correspondence Sridhar Hannenhalli. Email sridharh@. Maja Bucan. Email bucan@ Published I July 2009 Received 8 May 2009 Genome Biology 2009 10 R72 doi gb-2009-10-7-r72 Revisedj 2009 gy g Accepted I July 2009 The electronic version of this article is the complete one and can be found online at http 2009 10 7 R72 2009 Liu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hundreds of proteins modulate neurotransmitter release and synaptic plasticity during neuronal development and in response to synaptic activity. The expression of genes in the pre- and post-synaptic neurons is under stringent spatio-temporal control but the mechanism underlying the neuronal expression of these genes remains largely unknown. Results Using unbiased in vivo and in vitro screens we characterized the cis elements regulating the Rab3A gene which is expressed abundantly in presynaptic neurons. A set of identified regulatory elements of the Rab3A gene corresponded to the defined Rab3A multi-species conserved elements. In order to identify clusters of enriched transcription factor binding sites for example cis-regulatory modules we analyzed intergenic multi-species conserved elements in the vicinity of nine presynaptic genes including Rab3A that are highly and specifically expressed in brain regions. Sixteen transcription factor binding motifs were over-represented in these .

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