tailieunhanh - Báo cáo y học: "Genomic linkage map of the human blood fluke Schistosoma mansoni"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genomic linkage map of the human blood fluke Schistosoma mansoni. | Researc h Open Access Genomic linkage map of the human blood fluke Schistosoma mansoni Charles D Criscione Claudia LL Valentim Hirohisa Hirai Philip T LoVerde and Timothy JC Anderson Addresses Department of Biology Texas A M University College Station TX 77843 USA. Departments of Biochemistry and Pathology University of Texas Health Science Center San Antonio Texas 78229 USA. Department of Genetics Southwest Foundation for Biomedical Research San Antonio Texas 78245 USA. Primate Research Institute Kyoto University Inuyama Aichi 484-8506 Japan. Correspondence Charles D Criscione. Email ccriscione@ Published 30 June 2009 Genome Biology 2009 10 R71 doi gb-2009- l0-6-r7l The electronic version of this article is the complete one and can be found online at http 2009 l0 6 R7l Received 3 February 2009 Revised 7 April 2009 Accepted 30 June 2009 2009 Criscione et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Schistosoma mansoni is a blood fluke that infects approximately 90 million people. The complete life cycle of this parasite can be maintained in the laboratory making this one of the few experimentally tractable human helminth infections and a rich literature reveals heritable variation in important biomedical traits such as virulence host-specificity transmission and drug resistance. However there is a current lack of tools needed to study S. mansoni s molecular quantitative and population genetics. Our goal was to construct a genetic linkage map for S. mansoni and thus provide a new resource that will help stimulate research on this neglected pathogen. Results We genotyped grandparents parents and 88 progeny to construct a cM linkage map containing 243 .