tailieunhanh - Báo cáo sinh học: " Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort | Virology Journal BioMed Central Open Access Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort Haran Sivakumaran1 2 Bin Wang3 M John Gill4 Brenda Beckholdt4 Nitin K Saksena3 and David Harrich 1 Address 1Division of Infectious Diseases and Immunology Queensland Institute of Medical Research Brisbane Queensland Australia 2School of Population Health The University of Queensland Brisbane Queensland Australia 3Retroviral Genetics Group Centre for Virus Research Westmead Millennium Institute Westmead Hospital The University of Sydney Westmead New South Wales Australia and 4Department of Medicine University of Calgary . Calgary Alberta Canada Email Haran Sivakumaran - Bin Wang - bin_wang@ M John Gill - Brenda Beckholdt - Nitin K Saksena - nitin_saksena@ David Harrich - davidH@ Corresponding author Published 25 October 2007 Received 24 August 2007 Accepted 25 October 2007 Virology Journal 2007 4 107 doi 1743-422X-4-107 This article is available from http content 4 1 107 2007 Sivakumaran et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Here we investigated the nature and functional consequences of mutations in the HIV-1 tat gene within an epidemiologically-linked AIDS transmission cohort consisting of a non-progressing donor A and two normal progressing recipients B and C . Multiple nonsynonymous mutations in the tat first exon were observed across time in all individuals. Some mutations demonstrated striking host specificity despite the cohort being infected with a common .