tailieunhanh - Báo cáo y học: "Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease | Open Access Researc h Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease Radu Dobrin Jun Zhu Cliona Molony Carmen Argman Mark L Parrish Sonia Carlson Mark F Allan Daniel Pomp and Eric E Schadt Addresses Rosetta Inpharmatics LLC Merck Co. Inc. Terry Avenue North Seattle Washington 98109 USA. Department of Animal Science University of Nebraska Lincoln NE 68508 USA. Department of Nutrition Cell and Molecular Physiology Carolina Center for Genome Science University of North Carolina Chapel Hill NC 27599 USA. Current address Pfizer Animal Health Animal Genetics Business Unit East 42nd Street New York NY 10017 USA. Current address Pacific Biosciences 1505 Adams Dr Menlo Park CA 94025 USA. Correspondence Eric E Schadt. Email eric_schadt@ Published 22 May 2009 Genome Biology 2009 10 R55 doi gb-2009- 10-5-r55 The electronic version of this article is the complete one and can be found online at http 2009 10 5 R55 Received 26 November 2008 Revised 12 February 2009 Accepted 22 May 2009 2009 Dobrin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues resulting in an energy imbalance at the systems level. Results To provide an inter-tissue view of obesity with respect to molecular states that are associated with physiological states we developed a framework for constructing tissue-to-tissue coexpression networks between genes in the hypothalamus liver or adipose tissue. These networks have a scale-free architecture and are strikingly independent of gene-gene