tailieunhanh - Báo cáo sinh học: " Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy | BioMed Central Virology Journal Research Open Access Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy Tie Han11 Yizhe Tang11 Hideyo Ugai1 Leslie E Perry1 Gene P Siegal2 4 Juan L Contreras3 and Hongju Wu 1 5 6 Address 1Division of Human Gene Therapy Department of Medicine University of Alabama at Birmingham Birmingham USA 2Division of Human Gene Therapy Departments of Pathology University of Alabama at Birmingham Birmingham USA 3Division of Human Gene Therapy Departments of Surgery University of Alabama at Birmingham Birmingham USA 4Division of Human Gene Therapy Departments of Cell Biology University of Alabama at Birmingham Birmingham USA 5Division of Human Gene Therapy Departments of Obstetrics and Gynecology University of Alabama at Birmingham Birmingham USA and 6Gene Therapy Center University of Alabama at Birmingham Birmingham USA Email Tie Han - than@ Yizhe Tang - tyzhet@ Hideyo Ugai - hugai@ Leslie E Perry - perrylpl@ Gene P Siegal - gsiegal@ Juan L Contreras - jcontrer@ Hongju Wu - hongjuwu@ Corresponding author fEqual contributors Published 24 October 2007 Received 22 August 2007 Accepted 24 October 2007 Virology Journal 2007 4 103 doi 1743-422X-4-103 This article is available from http content 4 1 103 2007 Han et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human adenovirus serotype 5 Ad5 has been widely explored as a gene delivery vector for a variety of diseases. Many target cells however express low levels of Ad5 native receptor the Coxsackie-Adenovirus Receptor CAR and thus are resistant to Ad5 infection. The Protein Transduction Domain of the HIV .