tailieunhanh - Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data | Open Access Researc h Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data Yvonne JK Edwards Anna E Lobley Melissa M Pentony and David T Jones Address Bioinformatics Group Department of Computer Science University College London Gower Street London WC1E 6BT UK. These authors contributed equally to this work. Correspondence David T Jones. Email Published II May 2009 Genome Biology 2009 10 R50 doi gb-2009- I0-5-r50 The electronic version of this article is the complete one and can be found online at http 2009 I0 5 R50 Received I6 December 2008 Revised 23 March 2009 Accepted I I May 2009 2009 Edwards et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Disordered proteins need to be expressed to carry out specified functions however their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation. Gene expression levels mRNA decay rates microRNA miRNA targeting and ubiquitination have critical roles in the degradation and disposal of human proteins and transcripts. Here we describe a study examining these features to gain insights into the regulation of disordered proteins. Results In comparison with ordered proteins disordered proteins have a greater proportion of predicted ubiquitination sites. The transcripts encoding disordered proteins also have higher proportions of predicted miRNA target sites and higher mRNA decay rates both of which are indicative of the observed lower gene expression levels. The results suggest that the disordered proteins and their transcripts are present in the cell at low levels and or for a short time .