tailieunhanh - Insecticides Pest Engineering Part 4

Tham khảo tài liệu 'insecticides pest engineering part 4', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Organophosphorus Insecticides and Glucose Homeostasis 79 which per se did not interfere with lipid profile in rats yet causing augmentation of alteration in lipid profile in diabetic rats. However other studies have clearly demonstrated that several OPI cause alterations in lipid profile particularly hypertriglyceridemia Ryhanen et al 1984 Ibrahim El-Gamal 2003 Rezg et al. 2010 . Dyslipidemia or lipid abnormalities play an important role in the progression of diabetes Goldberg 2001 and these are characterized by lipid derangements including hypertriglyceridemia low high-density cholesterol HDL-C and a high concentration of small dense low-density lipoprotein LDL particles. Further a state of elevated hypertriglyceridemia is commonly associated with insulin resistance and represents a valuable clinical marker of the metabolic syndrome Grundy et al. 1999 . Propensity of OPI to induce hypertriglyceridemia coupled with their permissive effects of gluconeogenesis in liver creates a serious threat to glucose homeostasis. Fig. 9. Effect of repeated oral doses of monocrotophos at 1 20 LD50 mg kg on oxidative balance in kidney of control and diabetic rats Begum and Rajini 2011b . 4. Conclusion Given the status of OPI as environmental pollutant with residues being detected in biosphere around which are now being shown to make it into human body it is almost certain that OPI will interact with etiological factors of diabetes at toxicologically significant levels. Interaction of living system with OPI may have severe two-way impact on glycemic control. As documented facilitators of hepatic glucose output via glycogenolysis and gluconeogenesis OPI are most likely to elicit hyperglycaemic responses in humans during exposure. Further OPI may also affect the responsiveness to human system to insulin via 80 Insecticides - Pest Engineering multiple mechanisms causing predisposition to diabetes. From our studies it is also clear that OPI may also act to augment diabetic .

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