tailieunhanh - Báo cáo sinh học: " Cytopathic Mechanisms of HIV-1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cytopathic Mechanisms of HIV-1 | Virology Journal BioMed Central Review Cytopathic Mechanisms of HIV-1 Joshua M Costin Open Access Address Biotechnology Research Group Department of Biology Florida Gulf Coast University 10501 FGCU Blvd. S. Fort Myers Fl 33965 USA Email Joshua M Costin - jcostin@ Published 18 October 2007 Received 4 September 2007 Accepted 18 October 2007 Virology Journal 2007 4 100 doi I743-422X-4-I00 This article is available from http content 4 1 100 2007 Costin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The human immunodeficiency virus type 1 HIV-1 has been intensely investigated since its discovery in 1983 as the cause of acquired immune deficiency syndrome AIDS . With relatively few proteins made by the virus it is able to accomplish many tasks with each protein serving multiple functions. The Envelope glycoprotein composed of the two noncovalently linked subunits SU surface glycoprotein and TM transmembrane glycoprotein is largely responsible for host cell recognition and entry respectively. While the roles of the N-terminal residues of TM is well established as a fusion pore and anchor for Env into cell membranes the role of the C-terminus of the protein is not well understood and is fiercely debated. This review gathers information on TM in an attempt to shed some light on the functional regions of this protein. Review HIV discovery and clinical presentation In 1981 the CDC USA began noting a group of homosexual men presenting with symptoms of a rare opportunistic infections at a San Francisco clinic 1 2 . These patients were later found to be suffering from severe immune deficiency and their syndrome was dubbed acquired immune deficiency syndrome AIDS . In 1983 two viruses were .