tailieunhanh - Báo cáo y học: "A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans. | Open Access Researc h A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans Anna C Need Dalia Kasperaviciũtẻ Elizabeth T Cirulli and David B Goldstein Address Center for Human Genome Variation Institute for Genome Sciences and Policy Research Drive Duke University Durham NC 27708 USA. Correspondence David B Goldstein. Email Published 22 January 2009 Genome Biology 2009 10 R7 doi gb-2009-l 0-l-r7 The electronic version of this article is the complete one and can be found online at http 2009 10 l R7 Received 19 September 2008 Revised 16 December 2008 Accepted 22 January 2009 2009 Need et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It was recently shown that the genetic distinction between self-identified Ashkenazi Jewish and non-Jewish individuals is a prominent component of genome-wide patterns of genetic variation in European Americans. No study however has yet assessed how accurately self-identified Ashkenazi Jewish ancestry can be inferred from genomic information nor whether the degree of Jewish ancestry can be inferred among individuals with fewer than four Jewish grandparents. Results Using a principal components analysis we found that the individuals with full Jewish ancestry formed a clearly distinct cluster from those individuals with no Jewish ancestry. Using the position on the first principal component axis every single individual with self-reported full Jewish ancestry had a higher score than any individual with no Jewish ancestry. Conclusions Here we show that within Americans of European ancestry there is a perfect genetic .