tailieunhanh - Báo cáo sinh học: " Dengue virus serotype infection specifies the activation of the unfolded protein respon"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Dengue virus serotype infection specifies the activation of the unfolded protein respon | Virology Journal BioMed Central Research Open Access Dengue virus serotype infection specifies the activation of the unfolded protein response Indira Umareddy1 Olivier Pluquet2 Qing Yin Wang1 Subhash G Vasudevan1 Eric Chevet2 and Feng Gu 1 Address 1Novartis Institute for Tropical Diseases 10-Biopolis Road 05-01 Chromos 138670 Singapore and 2Team AVENIR GREF INSERM U899 IFR66 Université Victor Segalen Bordeaux 2 146 rue Léo Saignat 33076 Bordeaux France Email Indira Umareddy- Olivier Pluquet- Qing Yin Wang - Subhash G Vasudevan - Eric Chevet - Feng Gu - Corresponding author Published 24 September 2007 Received 22 May 2007 Accepted 24 September 2007 Virology Journal 2007 4 91 doi l 743-422X-4-91 This article is available from http content 4 1 91 2007 Umareddy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dengue and Dengue hemorrhagic fever have emerged as some of the most important mosquito-borne viral diseases in the tropics. The mechanisms of pathogenesis of Dengue remain elusive. Recently virus-induced apoptosis mediated by the Unfolded Protein Response UPR has been hypothesised to represent a crucial pathogenic event in viral infection. In an attempt to evaluate the contribution of the UPR to virus replication we have characterized each component of this signalling pathway following Dengue virus infection. Results We find that upon Dengue virus infection A549 cells elicit an UPR which is observed at the level of translation attenuation as visualized by the phosphorylation of eIF2alpha and activation of .