tailieunhanh - Báo cáo y học: "The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. | Open Access The FANTOM web resource from mammalian transcriptional landscape to its dynamic regulation Hideya Kawaji Jessica Severin Marina Lizio Andrew Waterhouse Shintaro Katayama Katharine M Irvine David A Hume Alistair RR Forrest Harukazu Suzuki Piero Carninci Yoshihide Hayashizaki and Carsten O Daub Addresses RIKEN Omics Science Center RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan. Institute for Molecular Bioscience University of Queensland Brisbane St Lucia QLD 4072 Australia. The Roslin Institute and Royal Dick School ofVeterinary Studies The University of Edinburgh Roslin EH259PS UK. The Eskitis Institute for Cell and Molecular Therapies Griffith University QLD 4111 Australia. Correspondence Hideya Kawaji. Email kawaji@ Published 19 April 2009 Genome Biology 2009 10 R40 doi gb-2009- 10-4-r40 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R40 Received 17 November 2008 Revised 9 March 2009 Accepted 19 April 2009 2009 Kawaji et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In FANTOM4 an international collaborative research project we collected a wide range of genome-scale data including 24 million mRNA 5 -reads CAGE tags and microarray expression profiles along a differentiation time course of the human THP-1 cell line and under 52 systematic siRNA perturbations. In addition data regarding chromatin status derived from ChIP-chip to elucidate the transcriptional regulatory interactions are included. Here we present these data to the research community as an integrated web resource. Background The Functional Annotation of the Mammalian Genome FANTOM consortium is an .