tailieunhanh - Báo cáo y học: "NetGrep: fast network schema searches in interactomes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: NetGrep: fast network schema searches in interactomes. | Open Access Software NetGrep fast network schema searches in interactomes Eric Banks Elena Nabieva Ryan Peterson and Mona Singh Addresses Department of Computer Science Princeton University 35 Olden Street Princeton NJ 08540 USA. Lewis-Sigler Institute for Integrative Genomics Princeton University Carl Icahn Lab Princeton NJ 08544 USA. Current address Department of Computer Science Cornell University 4130 Upson Hall Ithaca NY 14853 USA. Correspondence Mona Singh. Email msingh@ Published 18 September 2008 Genome Biology 2008 9 R138 doi gb-2008-9-9-r1 38 The electronic version of this article is the complete one and can be found online at http content 9 9 R138 Received 11 May 2008 Revised 22 August 2008 Accepted l8 September 2008 2008 Banks et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract NetGrep http singhlab netgrep is a system for searching protein interaction networks for matches to user-supplied network schemas . Each schema consists of descriptions of proteins for example their molecular functions or putative domains along with the desired topology and types of interactions among them. Schemas can thus describe domaindomain interactions signaling and regulatory pathways or more complex network patterns. NetGrep provides an advanced graphical interface for specifying schemas and fast algorithms for extracting their matches. Rationale High-throughput experimental and computational approaches to characterize proteins and their interactions have resulted in large-scale biological networks for many organisms. These complex networks are composed of a number of distinct types of interactions these include interactions between proteins that interact .