tailieunhanh - Báo cáo y học: "Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. | Researc h Open Access Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes Suganthi Balasubramanian Deyou Zheng Yuen-Jong Liu Gang Fang Adam Frankish Nicholas Carriero Rebecca Robilotto Philip Cayting and Mark Gerstein Addresses Department of Molecular Biophysics and Biochemistry Yale University 266 Whitney Avenue New Haven CT 06520 USA. The Saul R Korey Department of Neurology Albert Einstein College of Medicine NY 10461 USA. Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridgeshire CB10 1HH UK. Department of Computer Science Yale University New Haven CT 06520 USA. Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 USA. Correspondence Mark Gerstein. Email Published 5 January 2009 Genome Biology 2009 10 R2 doi gb-2009-l 0-l-r2 The electronic version of this article is the complete one and can be found online at http 2009 l0 l R2 Received 2l November 2008 Accepted 5 January 2009 2009 Balasubramanian et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The availability of genome sequences of numerous organisms allows comparative study of pseudogenes in syntenic regions. Conservation of pseudogenes suggests that they might have a functional role in some instances. Results We report the first large-scale comparative analysis of ribosomal protein pseudogenes in four mammalian genomes human chimpanzee mouse and rat . To this end we have assigned these pseudogenes in the four organisms using an automated pipeline and make the results available online. Each organism has a large number of ribosomal protein pseudogenes approximately l 400 to 2 800 . The majority of .