tailieunhanh - Báo cáo y học: "Taxonomic distribution of large DNA viruses in the sea"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Taxonomic distribution of large DNA viruses in the sea. | Open Access Research Taxonomic distribution of large DNA viruses in the sea Adam Monier Jean-Michel Claverie and Hiroyuki Ogata Address Structural and Genomic Information Laboratory CNRS-UPR 2589 IFR-88 Université de la Méditerranée Parc Scientifique de Luminy avenue de Luminy FR-13288 Marseille France. Correspondence Hiroyuki Ogata. Email Published 3 July 2008 Genome Biology 2008 9 R106 doi gb-2008-9-7-r106 The electronic version of this article is the complete one and can be found online at http 2008 9 7 R106 Received 15 February 2008 Revised 20 May 2008 Accepted 3 July 2008 2008 Monier et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Viruses are ubiquitous and the most abundant biological entities in marine environments. Metagenomics studies are increasingly revealing the huge genetic diversity of marine viruses. In this study we used a new approach - phylogenetic mapping - to obtain a comprehensive picture of the taxonomic distribution of large DNA viruses represented in the Sorcerer II Global Ocean Sampling Expedition metagenomic data set. Results Using DNA polymerase genes as a taxonomic marker we identified 811 homologous sequences of likely viral origin. As expected most of these sequences corresponded to phages. Interestingly the second largest viral group corresponded to that containing mimivirus and three related algal viruses. We also identified several DNA polymerase homologs closely related to Asfarviridae a viral family poorly represented among isolated viruses and until now limited to terrestrial animal hosts. Finally our approach allowed the identification of a new combination of genes in viral-like sequences. Conclusion .