tailieunhanh - Báo cáo y học: "Gene regulation and signal transduction in the immune system"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Gene regulation and signal transduction in the immune system. | Meeting report Gene regulation and signal transduction in the immune system Tiffany Horng Shalini Oberdoerffer and Anjana Rao Address Department of Pathology Harvard Medical School Immune Disease Institute Boston Massachusetts 02115 USA. Correspondence Tiffany Horng. Email horng@ Published 10 July 2008 Genome Biology 2008 9 315 doi gb-2008-9-7-315 The electronic version of this article is the complete one and can be found online at http 2008 9 7 315 2008 BioMed Central Ltd A report of the meeting Gene Expression and Signaling in the Immune System Cold Spring Harbor USA 22-26 April 2008. Major themes at this year s Cold Spring Harbor meeting on gene expression and signaling in the immune system included transcriptional control of leukocyte development and differentiation antigen receptor gene assembly and modification signal transduction by antigen receptors in control of lymphocyte biology signal transduction in regulation of inflammatory gene expression and the analysis of chromatin structure and other epigenetic mechanisms in control of gene expression. Metabolic regulation in lymphocyte activation The link between metabolism and regulation of lymphocyte activity was addressed by Doreen Cantrell University of Dundee UK who presented data regarding the role of phosphatidylinositol-3-OH kinase PI3K signaling in regulating T-cell biology. She has used an in vitro model of murine CD8 T-cell differentiation in which the strength of PI3K signaling is varied by culture with either of the cytokines interleukin IL -2 or IL-15 or with pharmacological inhibitors of the PI3K pathway. She showed that high levels of PI3K signaling as in the IL-2 cultures produced large cells with an effector phenotype while low levels as with IL-15 resulted in small memorylike cells. This reflected regulation of two major functional programs metabolism through control of protein synthesis and trafficking through regulated expression of the chemokine .