tailieunhanh - Báo cáo y học: "Integrating systems biology with clinical research"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Integrating systems biology with clinical research. | Meeting report Integrating systems biology with clinical research Rainer Pepperkok and Stefan Wiemann Addresses Cell Biology and Cell Biophysics Unit European Molecular Biology Laboratory Meyerhofstrasse 1 69117 Heidelberg Germany. Division of Molecular Genome Analysis German Cancer Research Center Im Neuenheimer Feld 580 69120 Heidelberg Germany. Correspondence Rainer Pepperkok. Email Pepperko@ Published 1 July 2008 Genome Biology 2008 9 314 doi gb-2008-9-7-314 The electronic version of this article is the complete one and can be found online at http 2008 9 7 314 2008 BioMed Central Ltd A report on the conference Systems Genomics 2008 Heidelberg Germany 2-3 May 2008. High-throughput techniques in genomics proteomics and cell biology hold the promise of systems-level analyses to elucidate fundamental biological principles and to understand and predict the behavior of cellular systems in health and disease. With this challenge in mind the recent Systems Genomics 2008 conference http mga SG2008 in Heidelberg brought together researchers in the fields of genomics functional genomics and systems biology to discuss the latest technological developments and their possible implications for clinical research. Systems and biological networks Two keynote presentations dealt with the understanding of interaction networks and with the implications of such knowledge for developing new therapeutic strategies in cancer. Peter Sorger Harvard Medical School Boston USA highlighted the central role of stochastic processes in the fate of cells and of the importance of determining them quantitatively. He and his colleagues have shown that even in a visually homogeneous cell population not all cells react the same way in response to a specific perturbation. While the causes of such an effect are complicated enough for binary decisions like apoptosis differentiation or cell division they will be even more so for continuous events such as .

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