tailieunhanh - Báo cáo y học: "Evolutionary-new centromeres preferentially emerge within gene deserts"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolutionary-new centromeres preferentially emerge within gene deserts. | Open Access Research Evolutionary-new centromeres preferentially emerge within gene deserts Mariana Lomiento Zhaoshi Jiang Pietro D Addabbo Evan E Eichler and Mariano Rocchi Addresses Department of Genetics and Microbiology University of Bari Via Amendola 165 A Bari 70126 Italy. Department of Genome Sciences University of Washington School of Medicine Seattle 1705 NE Pacific St Seattle WA 98195 USA. Howard Hughes Medical Institute 1705 NE Pacific St Seattle WA 98195 USA. Correspondence Mariano Rocchi. Email rocchi@ Published 16 December 2008 Genome Biology 2008 9 R173 doi gb-2008-9- 12-r 173 The electronic version of this article is the complete one and can be found online at http 2008 9 12 R173 Received 15 July 2008 Revised 15 November 2008 Accepted l6 December 2008 2008 Lomiento et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Evolutionary-new centromeres ENCs result from the seeding of a centromere at an ectopic location along the chromosome during evolution. The novel centromere rapidly acquires the complex structure typical of eukaryote centromeres. This phenomenon has played an important role in shaping primate karyotypes. A recent study on the evolutionary-new centromere of macaque chromosome 4 human 6 showed that the evolutionary-new centromere domain was deeply restructured following the seeding with respect to the corresponding human region assumed as ancestral. It was also demonstrated that the region was devoid of genes. We hypothesized that these two observations were not merely coincidental and that the absence of genes in the seeding area constituted a crucial condition for the evolutionary-new centromere fixation in the population. Results