tailieunhanh - Báo cáo y học: "MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs. | Software Open Access MotifCluster an interactive online tool for clustering and visualizing sequences using shared motifs Micah Hamady Jeremy Widmann Shelley D Copley and Rob Knight Addresses Department of Computer Science University of Colorado Boulder CO 80309 USA. Department of Chemistry and Biochemistry University of Colorado Boulder CO 80309 USA. Department of Molecular Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences CIRES University of Colorado Boulder CO 80309 USA. Correspondence Rob Knight. Email rob@ Published 15 August 2008 Genome Biology 2008 9 Rl28 doi gb-2008-9-8-rl 28 The electronic version of this article is the complete one and can be found online at http 2008 9 8 Rl28 Received 12 February 2008 Revised 23 June 2008 Accepted l5 August 2008 2008 Hamady et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract MotifCluster finds related motifs in a set of sequences and clusters the sequences into families using the motifs they contain. MotifCluster at http motifcluster lets users test whether proteins are related cluster sequences by shared conserved motifs and visualize motifs mapped onto trees sequences and three-dimensional structures. We demonstrate MotifCluster s accuracy using gold-standard protein superfamilies using recommended settings families were assigned to the correct superfamilies with false positive and no false negative assignments. Rationale Detection of evolutionary relationships between very distantly related protein families is important for efforts to assign functions to newly identified proteins as well as to understand the evolutionary mechanisms by which new .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.