tailieunhanh - Báo cáo y học: "Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences. | Research Open Access Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences Laurence Ettwiller Aidan Budd Frangois Spitz and Joachim Wittbrodt Addresses Developmental Biology Unit EMBL-Heidelberg MeyerhofstraBe 1 Heidelberg 69117 Germany. Structural and Computational Biology Unit EMBL-Heidelberg MeyerhofstraBe 1 Heidelberg 69117 Germany. Current address Heidelberg Institute of Zoology University of Heidelberg Im Neuenheimer Feld 230 Heidelberg 69120 Germany. Current address Institute of Toxicology and Genetics Forschungszentrum Karlsruhe Hermann-von-Helmholtz-Platz 1 Karlsruhe 76021 Germany. Correspondence Laurence Ettwiller. Email ettwille@ Published 16 December 2008 Genome Biology 2008 9 R172 doi gb-2008-9- 12-r 172 The electronic version of this article is the complete one and can be found online at http 2008 9 12 R172 Received 28 September 2008 Revised 1 December 2008 Accepted l6 December 2008 2008 Ettwiller et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Changes in gene regulation are suspected to comprise one of the driving forces for evolution. To address the extent of c s-regulatory changes and how they impact on gene regulatory networks across eukaryotes we systematically analyzed the evolutionary dynamics of target gene batteries controlled by 16 different transcription factors. Results We found that gene batteries show variable conservation within vertebrates with slow and fast evolving modules. Hence while a key gene battery associated with the cell cycle is conserved throughout metazoans the POU5F1 Oct4 and SOX2 batteries in embryonic stem cells show strong conservation within mammals with the .