tailieunhanh - Báo cáo y học: "Comparative genomics using Fugu reveals insights into regulatory subfunctionalization"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative genomics using Fugu reveals insights into regulatory subfunctionalization. | Open Access Research Comparative genomics using Fugu reveals insights into regulatory subfunctionalization Adam Woolfe Ỷ and Greg Elgar Addresses School of Biological Sciences Queen Mary University of London Mile End Road London E1 4NS UK. Genomic Functional Analysis Section National Human Genome Research Institute National Institutes of Health Rockville MD 20870 USA. Correspondence Adam Woolfe. Email woolfea@ Published II April 2007 Genome Biology 2007 8 R53 doi I86 gb-2007-8-4-r53 The electronic version of this article is the complete one and can be found online at http 2007 8 4 R53 Received I December 2006 Revised 6 March 2007 Accepted II April 2007 2007 Woolfe and Elgar licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A major mechanism for the preservation of gene duplicates in the genome is thought to be mediated via loss or modification of c s-regulatory subfunctions between paralogs following duplication a process known as regulatory subfunctionalization . Despite a number of gene expression studies that support this mechanism no comprehensive analysis of regulatory subfunctionalization has been undertaken at the level of the distal c s-regulatory modules involved. We have exploited fish-mammal genomic alignments to identify and compare more than 800 conserved non-coding elements CNEs that associate with genes that have undergone fish-specific duplication and retention. Results Using the abundance of duplicated genes within the Fugu genome we selected seven pairs of teleost-specific paralogs involved in early vertebrate development each containing clusters of CNEs in their vicinity. CNEs present around each Fugu duplicated gene were identified using multiple .