tailieunhanh - Báo cáo y học: "Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants. | Open Access Research Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants Sophie Gaudriault Sylvie Pages Anne Lanois Christine Laroui Corinne Teyssier Estelle Jumas-Bilak and Alain Givaudan Addresses INRA UMR 1133 Laboratoire EMIP Place Eugène Bataillon F-34095 Montpellier France. fUniversité Montpellier 2 UMR 1133 Laboratoire EMIP Place Eugène Bataillon F-34095 Montpellier France. Université Montpellier 1 EA 3755 Laboratoire de Bactériologie-Virologie 15 Avenue Charles Flahault BP 14491 F-34060 Montpellier Cedex 5 France. Correspondence Sophie Gaudriault. Email sgaudriault@ Published 22 July 2008 Genome Biology 2008 9 R117 doi gb-2008-9-7-r1 17 The electronic version of this article is the complete one and can be found online at http 2008 9 7 R117 Received 15 April 2008 Revised 12 June 2008 Accepted 22 July 2008 2008 Gaudriault et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The phenotypic consequences of large genomic architecture modifications within a clonal bacterial population are rarely evaluated because of the difficulties associated with using molecular approaches in a mixed population. Bacterial variants frequently arise among Photorhabdus luminescens a nematode-symbiotic and insect-pathogenic bacterium. We therefore studied genome plasticity within Photorhabdus variants. Results We used a combination of macrorestriction and DNA microarray experiments to perform a comparative genomic study of different P. luminescens TT01 variants. Prolonged culturing of TT01 strain and a genomic variant collected from the laboratory-maintained symbiotic nematode generated bacterial lineages composed of primary and .