tailieunhanh - Báo cáo y học: "Evolution of protein complexes by duplication of homomeric interactions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolution of protein complexes by duplication of homomeric interactions. | Open Access Research Evolution of protein complexes by duplication of homomeric interactions Jose B Pereira-Leal Emmanuel D Levy Christel Kamp and Sarah A Teichmann Addresses Institute Gulbenkian de Ciência Apartado 14 P-2781-901 Oeiras Portugal. MRC Laboratory of Molecular Biology Hills Road Cambridge CB2 2QH UK. Paul-Ehrlich-Institut Federal Agency for Sera and Vaccines Paul-Ehrlich-Strabe 63225 Langen Germany. Correspondence Jose B Pereira-Leal. Email jleal@ Published 5 April 2007 Genome Biology 2007 8 R51 doi gb-2007-8-4-r51 The electronic version of this article is the complete one and can be found online at http 2007 8 4 R51 Received 3 October 2006 Revised 15 January 2007 Accepted 5 April 2007 2007 Pereira-Leal et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes modules in physical protein-protein interaction networks. Results We studied protein complexes in Saccharomyces cerevisiae complexes of known threedimensional structure in the Protein Data Bank and clusters of pairwise protein interactions in the networks of several organisms. We found that duplication of homomeric interactions a large class of protein interactions frequently results in the formation of complexes of paralogous proteins. This route is a common mechanism for the evolution of complexes and clusters of protein interactions. Our conclusions are further confirmed by theoretical modelling of network evolution. We propose reasons for why this is .