tailieunhanh - Báo cáo y học: "Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. | Open Access Research Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip Shilpi Arora Yipeng Wang Zhenyu Jia Saynur Vardar-Sengul Ayla Munawar Kutbuddin S Doctor Michael Birrer Michael McClelland Eileen Adamson and Dan Mercola Addresses Department of Pathology and Laboratory Medicine University of California Irvine CA 92697 USA. Sidney Kimmel Cancer Center San Diego CA 92121 USA. Department of Periodontology School of Dentistry Ege University Bornova 35100 Izmir Turkey. Burnham Institute for Medical Research La Jolla CA 92037 USA. National Institutes of Health Cell and Cancer Biology Branch National Cancer Institute Bethesda MD 20892 USA. Correspondence Dan Mercola. Email dmercola@ Published 25 November 2008 Genome Biology 2008 9 R166 doi gb-2008-9- 11-r166 The electronic version of this article is the complete one and can be found online at http 2008 9 11 R166 Received 10 October 2008 Accepted 25 November 2008 2008 Arora et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background UV irradiation activates the epidermal growth factor receptor induces Egr 1 expression and promotes apoptosis in a variety of cell types. We examined the hypothesis that Egr1 regulates genes that mediate this process by use of a chip-on-chip protocol in human tumorigenic prostate M12 cells. Results UV irradiation led to significant binding of 288 gene promoters by Egr1. A major functional subgroup consisted of apoptosis related genes. The largest subgroup of 24 genes belongs to the epidermal growth factor receptor-signal transduction pathway. Egr1 promoter binding had a significant impact on gene expression of target genes. Conventional .

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