tailieunhanh - Báo cáo y học: "Network-based approaches for linking metabolism with environment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: INetwork-based approaches for linking metabolism with environment. | Minireview Network-based approaches for linking metabolism with environment Sarath Chandra Janga and M Madan Babu Address MRC Laboratory of Molecular Biology Hills Road Cambridge CB2 0QH UK. Correspondence Sarath Chandra Janga. Email sarath@ Published 24 November2008 Genome Biology 2008 9 239 doi gb-2008-9-ll-239 The electronic version of this article is the complete one and can be found online at http 2008 9 11 239 2008 BioMed Central Ltd Abstract Progress in the reconstruction of genome-wide metabolic maps has led to the development of network-based computational approaches for linking an organism with its biochemical habitat. The sequential nature of the reactions in metabolic pathways means that they can be modeled in the form of a graph network of enzymes and chemical transformations and network theory can be used to represent and understand metabolism 1 2 . The connected collection of metabolic pathways describing the set of all enzymatic interconversions of one small molecule into another is defined as the metabolic network of an organism Figure 1a . The most commonly used network representations are metabolite-centric . They consider metabolites as the nodes of the graph and two metabolites are linked if one can be converted into the other by an enzymatic reaction Figure 1b left . An alternative network representation is enzyme-centric . It considers the enzymes as nodes and links enzymes that catalyze successive reactions Figure 1b right . Although several studies have provided insights into the structure and evolution of a metabolic network very few have addressed the influence of environment on metabolic network structure in species from diverse environmental conditions. The availability of many completely sequenced genomes means that metabolic-network analysis can now be extended from a few model organisms to species from different branches of the tree of life and living in very different environments. This .