tailieunhanh - Báo cáo y học: "Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome. | Open Access Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome Vicky Tsipouri Mary G Schueler Sufen Hu NISC Comparative Sequencing Program Amalia Dutra Evgenia Pak Harold Riethman and Eric D Green Addresses Genome Technology Branch National Human Genome Research Institute National Institutes of Health 50 South Dr. Bethesda Maryland 20892 USA. Molecular and Cellular Oncogenesis Wistar Institute 3601 Spruce Street Philadelphia Pennsylvania 19104 USA. NIH Intramural Sequencing Center NISC 5625 Fishers Ln. Rockville Maryland 20852 USA. Genetic Disease Research Branch National Human Genome Research Institute National Institutes of Health 49 Convent Dr. Bethesda Maryland 20892 USA. Correspondence Eric D Green. Email egreen@ Published 28 October 2008 Genome Biology 2008 9 R155 doi gb-2008-9- 10-r 155 The electronic version of this article is the complete one and can be found online at http 2008 9 10 R155 Received 29 July 2008 Revised 15 October 2008 Accepted 28 October 2008 2008 Tsipouri et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Indian muntjac Muntiacus muntjak vaginalis has an extreme mammalian karyotype with only six and seven chromosomes in the female and male respectively. Chinese muntjac Muntiacus reevesi has a more typical mammalian karyotype with 46 chromosomes in both sexes. Despite this disparity the two muntjac species are morphologically similar and can even interbreed to produce viable albeit sterile offspring. Previous studies have suggested that a series of telocentric chromosome fusion events involving telomeric and or satellite repeats led to the extant Indian muntjac karyotype. Results We .