tailieunhanh - Báo cáo y học: "The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes. | Open Access The transferome of metabolic genes explored analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes John W Whitaker Glenn A McConkey and David R Westhead Address Institute of Molecular and Cellular Biology University of Leeds Leeds West Yorkshire LS2 9JT UK. Correspondence David R Westhead. Email Published 15 April 2009 Genome Biology 2009 10 R36 doi gb-2009- 10-4-r36 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R36 Received 18 December 2008 Revised 6 April 2009 Accepted 15 April 2009 2009 Whitaker et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Metabolic networks are responsible for many essential cellular processes and exhibit a high level of evolutionary conservation from bacteria to eukaryotes. If genes encoding metabolic enzymes are horizontally transferred and are advantageous they are likely to become fixed. Horizontal gene transfer HGT has played a key role in prokaryotic evolution and its importance in eukaryotes is increasingly evident. High levels of endosymbiotic gene transfer EGT accompanied the establishment of plastids and mitochondria and more recent events have allowed further acquisition of bacterial genes. Here we present the first comprehensive multi-species analysis of E HGT of genes encoding metabolic enzymes from bacteria to unicellular eukaryotes. Results The phylogenetic trees of 2 257 metabolic enzymes were used to make E HGT assertions in ten groups of unicellular eukaryotes revealing the sources and metabolic processes of the transferred genes. Analyses revealed a preference for enzymes encoded by genes gained through .