tailieunhanh - Báo cáo y học: "Evolutionary rates and centrality in the yeast gene regulatory network"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolutionary rates and centrality in the yeast gene regulatory network. | Open Access Research Evolutionary rates and centrality in the yeast gene regulatory network Richard Jovelin and Patrick C Phillips Address Center for Ecology and Evolutionary Biology 5289 University of Oregon Eugene OR 97403 USA. Correspondence Richard Jovelin. Email rjovelin@ Published 9 April 2009 Genome Biology 2009 10 R35 doi gb-2009- 10-4-r35 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R35 Received 9 October 2008 Accepted 9 April 2009 2009 Jovelin and Phillips licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transcription factors play a fundamental role in regulating physiological responses and developmental processes. Here we examine the evolution of the yeast transcription factors in the context of the structure of the gene regulatory network. Results In contrast to previous results for the protein-protein interaction and metabolic networks we find that the position of a gene within the transcription network affects the rate of protein evolution such that more central transcription factors tend to evolve faster. Centrality is also positively correlated with expression variability suggesting that the higher rate of divergence among central transcription factors may be due to their role in controlling information flow and may be the result of adaptation to changing environmental conditions. Alternatively more central transcription factors could be more buffered against environmental perturbations and therefore less subject to strong purifying selection. Importantly the relationship between centrality and evolutionary rates is independent of expression level expression variability and gene essentiality. .