tailieunhanh - Báo cáo y học: "Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gond"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii. | Open Access Researc h Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii Nandita Mullapudi Sandeep J Joseph and Jessica C Kissinger Addresses Department of Genetics University of Georgia East Green Street Athens Georgia 30602 USA. Center for Tropical and Emerging Global Diseases University of Georgia DW Brooks Drive Athens Georgia 30602 USA. Current address Department of Pulmonary Medicine Albert Einstein College of Medicine Morris Park Ave Bronx New York NY 10461 USA. Correspondence Nandita Mullapudi. Email mnandita@. Jessica C Kissinger. Email jkissing@ Published 7 April 2009 Genome Biology 2009 10 R34 doi gb-2009- 10-4-r34 The electronic version of this article is the complete one and can be found online at http 2009 10 4 R34 Received 21 September 2008 Revised 11 January 2009 Accepted 7 April 2009 2009 Mullapudi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Toxoplasma gondii is a member of the phylum Apicomplexa which consists entirely of parasitic organisms that cause several diseases of veterinary and human importance. Fundamental mechanisms of gene regulation in this group of protistan parasites remain largely uncharacterized. Owing to their medical and veterinary importance genome sequences are available for several apicomplexan parasites. Their genome sequences reveal an apparent paucity of known transcription factors and the absence of canonical cis-regulatory elements. We have approached the question of gene regulation from a sequence perspective by mining the genomic sequence data to identify putative cis-regulatory elements using a de novo approach. Results We have .