tailieunhanh - Báo cáo y học: "Evolving proteins at Darwin's bicentenary"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolving proteins at Darwin's bicentenary. | Meeting report Evolving proteins at Darwin s bicentenary John W Pinney and Michael PH Stumpf Address Centre for Bioinformatics Division of Molecular Biosciences Imperial College London Wolfson Building London SW7 2AZ UK. Correspondence Michael PH Stumpf. Email Published 17 April 2009 Genome Biology 2009 10 307 doi gb-2009-10-4-307 The electronic version of this article is the complete one and can be found online at http 2009 10M 307 2009 BioMed Central Ltd A report of the Biochemical Society Wellcome Trust meeting Protein Evolution - Sequences Structures and Systems Hinxton UK 26-27 January 2009. The effects of natural selection are ultimately mediated through protein function. The traditional view that selection on proteins is primarily due to the effects of mutations on protein structure has however in recent years been replaced by a much richer picture. This modern perspective was in evidence at a recent meeting on protein evolution in Hinxton UK. Here we report some of the highlights. Unsurprisingly Charles Darwin featured at lot at the meeting. Evolutionary arguments are all-pervasive in the biomedical and life sciences and this is particularly true for the analysis of proteins and their role in cell and molecular biology. From initial investigations of individual proteins in the 1940s and 1950s which were motivated by even earlier work on blood groups we can now routinely collect information from a large number of sequenced genomes to help us understand the evolution of proteins in terms of their sequences structures and functions and their roles as parts of biological systems. Comparative evolution The primacy of comparative and thus evolutionary arguments in the analysis of proteins and their structure was emphasized by Tom Blundell University of Cambridge UK who reviewed almost 40 years of structural bioinformatics. He noted that in the early studies of insulin structure the common ancestry of all life on .