tailieunhanh - Báo cáo y học: " Malaria sporozoite proteome leaves a trail."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Malaria sporozoite proteome leaves a trail. | Minireview Malaria sporozoite proteome leaves a trail Marissa Vignali Cate Speake t and Patrick E Duffy t Addresses Malaria Program Seattle Biomedical Research Institute Seattle Washington 98109 USA. tDepartment of Global Health University of Washington Seattle Washington 98195 USA. Correspondence Patrick E Duffy. Email Published 21 April 2009 Genome Biology 2009 10 216 doi gb-2009-10-4-216 The electronic version of this article is the complete one and can be found online at http 2009 10M 216 2009 BioMed Central Ltd Abstract The malaria parasite sporozoite proteome changes during maturation revealing proteins specifically expressed in the stage that infects the human host. Every year malaria causes an estimated 250-500 million clinical cases worldwide resulting in nearly a million deaths. Despite growing awareness and substantial public-health efforts aimed at reducing the global malaria burden more than a billion people remain at risk of contracting the disease and control remains elusive there is currently no licensed vaccine and resistance has developed to nearly all available antimalarial drugs 1 . A study published recently by Lasonder and colleagues in PLoS Pathogens 2 applies a proteomicsbased reverse genetics approach to identify proteins expressed specifically in the stages that immediately precede human infection resulting in the identification of new candidates for drugs and vaccines that might prevent infection by Plasmodium falciparum. Malaria is caused by Plasmodium parasites which have a complex life cycle Figure 1 . Sexual parasite forms or gametocytes that are generated at low frequency during the blood stage are taken up in a mosquito bloodmeal. Gamete fertilization occurs in the mosquito midgut and the resulting zygote develops into an ookinete which penetrates the wall of the midgut and becomes an oocyst. The parasite then reproduces asexually within this membrane-bound form generating thousands .

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