tailieunhanh - Báo cáo y học: "Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions. | Open Access Researc h Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions Thiago M Venancio S Balaji Lakshminarayan M Iyer and L Aravind Address National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda Maryland 20894 USA. Correspondence Thiago M Venancio. Email venancit@. LAravind. Email aravind@ Published 30 March 2009 Genome Biology 2009 10 R33 doi gb-2009-l0-3-r33 The electronic version of this article is the complete one and can be found online at http 2009 10 3 R33 Received 1 December 2008 Revised 11 February 2009 Accepted 30 March 2009 2009 Venancio et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The ubiquitin system Ub-system can be defined as the ensemble of components including Ub ubiquitin-like proteins their conjugation and deconjugation apparatus binding partners and the proteasomal system. While several studies have concentrated on structurefunction relationships and evolution of individual components of the Ub-system a study of the system as a whole is largely lacking. Results Using numerous genome-scale datasets we assemble for the first time a comprehensive reconstruction of the budding yeast Ub-system revealing static and dynamic properties. We devised two novel representations the rank plot to understand the functional diversification of different components and the clique-specific point-wise mutual-information network to identify significant interactions in the Ub-system. Conclusions Using these representations evidence is provided for the functional diversification of components such as SUMO-dependent .