tailieunhanh - Báo cáo y học: "TFCat: the curated catalog of mouse and human transcription factors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: TFCat: the curated catalog of mouse and human transcription factors. | Software Open Access TFCat the curated catalog of mouse and human transcription factors Debra L Fulton Saravanan Sundararajan Gwenael Badis Timothy R Hughes Wyeth W Wasserman Jared C Roach and Rob Sladek Addresses Department of Medical Genetics Centre for Molecular Medicine and Therapeutics - Child and Family Research Institute University of British Columbia West 28th Avenue Vancouver V5Z 4H4 Canada. Departments of Medicine and Human Genetics McGill University and Genome Quebec Innovation Centre Dr. Penfield Avenue Montreal H3A 1A4 Canada. Banting and Best Department of Medical Research University of Toronto College Street Toronto M5S 3E1 Canada. Center for Developmental Therapeutics Seattle Children s Research Institute Olive Way Seattle 98101 USA. These authors contributed equally to this work. Correspondence Rob Sladek. Email Published 12 March 2009 Genome Biology 2009 10 R29 doi gb-2009- 10-3-r29 The electronic version of this article is the complete one and can be found online at http 2009 10 3 R29 Received 5 December 2008 Revised 26 February 2009 Accepted 12 March 2009 2009 Fulton et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Unravelling regulatory programs governed by transcription factors TFs is fundamental to understanding biological systems. TFCat is a catalog of mouse and human TFs based on a reliable core collection of annotations obtained by expert review of the scientific literature. The collection including proven and homology-based candidate TFs is annotated within a function-based taxonomy and DNA-binding proteins are organized within a classification system. All data and userfeedback mechanisms are available at the TFCat portal http .