tailieunhanh - Báo cáo y học: " PDGF/VEGF signaling controls cell size in Drosophila"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: PDGF/VEGF signaling controls cell size in Drosophila. | Open Access PDGF VEGF signaling controls cell size in Drosophila David Sims Peter Duchek and Buzz Baum Addresses Morphogenesis Group Ludwig Institute for Cancer Research UCL Branch Riding House Street London W1W 7BS UK. Current address The Breakthrough Toby Robins Breast Cancer Research Centre at the Institute of Cancer Research Chester Beatty Laboratories Fulham Road London SW3 6JB UK. Current address Institute of Molecular Biotechnology of the Austrian Academy of Sciences Dr Bohrgasse 1030 Vienna Austria. Current address MRC Laboratory for Molecular and Cell Biology University College London Gower Street London WciE 6BT UK. Correspondence Buzz Baum. Email Published 12 February 2009 Genome Biology 2009 I0 R20 doi gb-2009- 10-2-r20 The electronic version of this article is the complete one and can be found online at http 2009 10 2 R20 Received 21 November 2008 Accepted l2 February 2009 2009 Sims et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In multicellular animals cell size is controlled by a limited set of conserved intracellular signaling pathways which when deregulated contribute to tumorigenesis by enabling cells to grow outside their usual niche. To delineate the pathways controlling this process we screened a genome-scale image-based Drosophila RNA interference dataset for double-stranded RNAs that reduce the average size of adherent S2R cells. Results Automated analysis of images from this RNA interference screen identified the receptor tyrosine kinase Pvr Ras pathway components and several novel genes as regulators of cell size. Significantly Pvr Ras signaling also affected the size of other Drosophila cell lines and of larval hemocytes. A .